Odd how many of these I am currently using...
(I differ for IM, using Trillian for Windows and Fire for Mac. The alternatives recommented by the above link may indeed by superior, but I can't imagine how. Trillian even has ultra-cool variable semi-transparency for its windows.)
UPDATE: I realized these websites do not list free Bible software. If you use Windows, e-sword is not Open Source, but it's free and as good as anything that costs money.